Farmacocinética poblacional de la digoxina en pacientes de edad avanzada: Una revisión sistemática

Ángel Luis Salcedo-Mingoarranz, Benito García-Díaz, Emilia Barcia-Hernández

Resumen


Objetivo: Resumir la literatura disponible sobre los estudios de farmacocinética poblacional de digoxina en pacientes de edad avanzada e  identificar los cambios fisiopatológicos en esta subpoblación, que conllevan implicaciones clínicas en la farmacocinética de la digoxina.

Método: Se realizó una revisión sistemática de los estudios de farmacocinética poblacional en pacientes ancianos que recibían digoxina. Se  utilizaron PubMed, ISI Web of Science, SCOPUS y Science Direct para  identificar los artículos con los descriptores (“Digoxin”[Mesh]) AND (“Pharmacokinetics”[Mesh]) AND (“Aged”[Mesh] OR “Elderly”[Mesh]), seguido de una búsqueda manual.

Resultados: Se encontraron y revisaron nueve estudios, cinco de los cuales  de desarrollaron en pacientes asiáticos. Se utilizó NONMEM para el análisis  farmacocinético de los niveles plasmáticos de la digoxina, mayoritariamente  descrita como un modelo monocompartimental. 

Conclusiones: Los pacientes ancianos presentan cambios fisiopatológicos con  gran influencia en la farmacocinética de muchos fármacos. Las covariables con  un mayor impacto en la farmacocinética de la digoxina deben tenerse en  cuenta al ajustar la dosis de este medicamento en pacientes de edad avanzada  con el fin de lograr beneficios óptimos para la salud y prevenir  posibles efectos adversos en esta subpoblación.

 


Palabras clave


Population pharmacokinetics; Digoxin; Elderly; Systematic review

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Referencias


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DOI: http://dx.doi.org/10.7399%2Ffh.13288

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