Potential incompatibility of intravenous medications in the Neonatal Intensive Care Unit in Indonesia

Andika Dwi Mahendra; Suci Hanifah; Chynthia Pradiftha Sari

Potential incompatibility of intravenous medications in the Neonatal Intensive Care Unit in Indonesia

Andika Dwi Mahendra, Suci Hanifah, Chynthia Pradiftha Sari

Resumen

Objective : The purpose of this study is to determine the most common incompatible and unknown compatibility drug combinations and determine the compatibility of each pair of drugs used in hospitals based on reference books and journals.

Methods : This is a prospective cross sectional study. All babies who were admitted to the NICU from May 1 to July 31 were sample of the study. Patients who did not receive at least two drug coadministrated concurrently and less than 24 hours in the NICU were excluded. only drug-drug combinations were considered and the other non-drug administrations (electrolyte solutions, parenteral nutritions, and blood products) were excluded from this study. Compatibility data were obtained from literature and online search engines (micromedex NeoFax Essentials 2020, the UCL hospital guidelines, Trissel Handbook on injectable drugs 15^th edition, and published journal)

Results : The most commonly prescribed drug combinations were ampicillin-gentamicin (31.72%), amikacin-ampicillin sulbactam (9.05%), amikacin-ampicillin sulbactam-aminophyllin (3.08%). The most common drug incompatible combination was ampicillin - gentamicin (31.71%), for the most drug combinations whose compatibility unknown were amikacin-ampicillin sulbactam (9.05%).

Conclusions : The high prevalence of incompatible drugs and unknown compatibility, so checking its compatibility can be carried out through a two-dimensional chart to minimize the incidence of incompatibilities.

Palabras clave

intravenous medications; NICU; drug compatibility; indonesia hospital

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